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Cleft lip, lip and palate or palate

DOID EFO MESH Endpoint Browser PheWeb

Q17_CLEFT_LIP_CLEFT_PALATE

cleft lip: ['Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.']

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

not Q17_CLEFT_PALATE_EXCLUDE

428574

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 Q35-Q37
Hospital discharge: ICD-9 749
Hospital discharge: ICD-8 74900|74910|74911|74912|74913|74920|74924|74929
Cause of death: ICD-10 Q35-Q37
Cause of death: ICD-9 749
Cause of death: ICD-8 74900|74910|74911|74912|74913|74920|74924|74929

2 out of 7 registries used, show all original rules.

516

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Check minimum number of events None

516

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Include endpoints None

516

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Remove individuals based on genotype QC

495

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Q17_CLEFT_LIP_CLEFT_PALATE

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF7

Summary Statistics

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Key figures

All Female Male
Number of individuals 495 301 194
Unadjusted prevalence (%) 0.12 0.13 0.11
Mean age at first event (years) 11.71 11.45 12.12

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: Q17_CLEFT_LIP_CLEFT_PALATE – Cleft lip, lip and palate or palate
GWS hits: 4

Survival analyses between endpoints

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Plot

before Cleft lip, lip and palate or palate
after Cleft lip, lip and palate or palate

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cleft lip, lip and palate or palate

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Endpoint not on priority list, no data to show.