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Polycythaemia vera

DOID EFO MESH SNOMED Endpoint Browser PheWeb

POLYCYTVERA

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D45
Hospital discharge: ICD-9 2384
Hospital discharge: ICD-8 208
Cause of death: ICD-10 D45
Cause of death: ICD-9 2384
Cause of death: ICD-8 208
Cancer registry: Topography ICD-O-3 ANY
Cancer registry: Morphology ICD-O-3 9950
Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

1034

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Check minimum number of events None

1034

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Include endpoints None

1034

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Remove individuals based on genotype QC

1004

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POLYCYTVERA

Control definitions

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 1004 483 521
Unadjusted prevalence (%) 0.24 0.21 0.29
Mean age at first event (years) 63.19 63.35 63.05

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 5.77 [3.83, 8.69] 4.6e-17 243
15 years 0.02 3.38 [2.49, 4.59] 7.4e-15 123
5 years 0.01 3.75 [2.71, 5.20] 1.7e-15 64
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: POLYCYTVERA – Polycythaemia vera
GWS hits: 10

Survival analyses between endpoints

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Plot

before Polycythaemia vera
after Polycythaemia vera

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Drugs most likely to be purchased after Polycythaemia vera

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Endpoint not on priority list, no data to show.