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Pre-eclampsia or eclampsia

DOID EFO MESH SNOMED Endpoint Browser PheWeb

O15_PRE_OR_ECLAMPSIA

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule

Sex only females

239906

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Check conditions None

239906

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 O11, O14, O15
Hospital discharge: ICD-9 642[4-7]
Hospital discharge: ICD-8 6370[349]|63710|63799|66120
Cause of death: ICD-10 O11, O14, O15
Cause of death: ICD-9 642[4-7]
Cause of death: ICD-8 6370[349]|63710|63799|66120

2 out of 7 registries used, show all original rules.

8211

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Check minimum number of events None

8211

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Include endpoints None

8211

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Remove individuals based on genotype QC

7965

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O15_PRE_OR_ECLAMPSIA

Control definitions

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 7965 7965 -
Unadjusted prevalence (%) 1.93 3.46 -
Mean age at first event (years) 29.00 29.00 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.52 [0.38, 0.71] 3.1e-5 182
15 years 0.00 0.28 [0.19, 0.42] 1.9e-9 37
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_PRE_OR_ECLAMPSIA – Pre-eclampsia or eclampsia
GWS hits: 5

Survival analyses between endpoints

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Plot

before Pre-eclampsia or eclampsia
after Pre-eclampsia or eclampsia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Pre-eclampsia or eclampsia

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Endpoint not on priority list, no data to show.