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Pre-eclampsia

DOID EFO MESH SNOMED Endpoint Browser PheWeb

O15_PREECLAMPS

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule

Sex only females

239906

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Check conditions None

239906

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 O14
Hospital discharge: ICD-9 642[4-5]
Hospital discharge: ICD-8 6370[349]
Cause of death: ICD-10 O14
Cause of death: ICD-9 642[4-5]
Cause of death: ICD-8 6370[349]

2 out of 7 registries used, show all original rules.

7612

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Check minimum number of events None

7612

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Include endpoints None

7612

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Remove individuals based on genotype QC

7377

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O15_PREECLAMPS

Control definitions

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O10-O16
Name in latin Hypertensio gestationalis cum proteinuria significanti

Summary Statistics

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Key figures

All Female Male
Number of individuals 7377 7377 -
Unadjusted prevalence (%) 1.79 3.20 -
Mean age at first event (years) 29.04 29.04 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 0.74 [0.55, 1.01] 5.6e-2 158
15 years 0.00 0.41 [0.27, 0.62] 2.7e-5 33
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_PREECLAMPS – Pre-eclampsia
GWS hits: 3

Survival analyses between endpoints

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Plot

before Pre-eclampsia
after Pre-eclampsia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Pre-eclampsia

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Endpoint not on priority list, no data to show.