Pre-eclampsia

O15_PREECLAMPS

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule

Sex only females

239906

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Check conditions None

239906

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 O14
Hospital discharge: ICD-9 642[4-5]
Hospital discharge: ICD-8 6370[349]
Cause of death: ICD-10 O14
Cause of death: ICD-9 642[4-5]
Cause of death: ICD-8 6370[349]

2 out of 7 registries used, show all original rules.

7612

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Check minimum number of events None

7612

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Include endpoints None

7612

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Remove individuals based on genotype QC

7377

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O15_PREECLAMPS

Control definitions

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O10-O16
Name in latin Hypertensio gestationalis cum proteinuria significanti

Summary Statistics

Key figures

All Female Male
Number of individuals 7377 7377 -
Unadjusted prevalence (%) 1.79 3.20 -
Mean age at first event (years) 29.04 29.04 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 0.74 [0.55, 1.01] 5.6e-2 158
15 years 0.00 0.41 [0.27, 0.62] 2.7e-5 33
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: O15_PREECLAMPS – Pre-eclampsia
GWS hits: 3

Survival analyses between endpoints

Plot

before Pre-eclampsia
after Pre-eclampsia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Pre-eclampsia

Endpoint not on priority list, no data to show.