Gestational [pregnancy-induced] hypertension

O15_GESTAT_HYPERT

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule

Sex only females

239906

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Check conditions None

239906

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 O13
Hospital discharge: ICD-9 6423
Hospital discharge: ICD-8 63701
Cause of death: ICD-10 O13
Cause of death: ICD-9 6423
Cause of death: ICD-8 63701

2 out of 7 registries used, show all original rules.

9782

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Check minimum number of events None

9782

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Include endpoints None

9782

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Remove individuals based on genotype QC

9535

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O15_GESTAT_HYPERT

Control definitions

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O10-O16
Name in latin Hypertensio gestationalis sine proteinuria significanti

Summary Statistics

Key figures

All Female Male
Number of individuals 9535 9535 -
Unadjusted prevalence (%) 2.31 4.14 -
Mean age at first event (years) 30.06 30.06 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 0.77 [0.53, 1.12] 1.7e-1 202
15 years 0.00 0.57 [0.37, 0.86] 7.4e-3 57
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: O15_GESTAT_HYPERT – Gestational [pregnancy-induced] hypertension
GWS hits: 13

Survival analyses between endpoints

Plot

before Gestational [pregnancy-induced] hypertension
after Gestational [pregnancy-induced] hypertension

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Drugs most likely to be purchased after Gestational [pregnancy-induced] hypertension

Endpoint not on priority list, no data to show.