Macular hole

MACULAR_HOLE

macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.37#
Hospital discharge: ICD-9 3625D
Cause of death: ICD-10 H35.37#
Cause of death: ICD-9 3625D

2 out of 7 registries used, show all original rules.

1407

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Check minimum number of events None

1407

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Include endpoints None

1407

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Remove individuals based on genotype QC

1368

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MACULAR_HOLE

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35

Summary Statistics

Key figures

All Female Male
Number of individuals 1368 817 551
Unadjusted prevalence (%) 0.33 0.35 0.30
Mean age at first event (years) 70.23 68.71 72.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 5.66 [3.34, 9.59] 1.2e-10 110
15 years 0.01 2.01 [1.13, 3.57] 1.7e-2 39
5 years 0.01 5.12 [3.30, 7.94] 3.1e-13 56
1 year 0.00 5.87 [3.21, 10.71] 8.6e-9 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 3

Survival analyses between endpoints

Plot

before Macular hole
after Macular hole

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Macular hole

Endpoint not on priority list, no data to show.