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Macular hole

DOID EFO MESH SNOMED Endpoint Browser PheWeb

MACULAR_HOLE

macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.37#
Hospital discharge: ICD-9 3625D
Cause of death: ICD-10 H35.37#
Cause of death: ICD-9 3625D

2 out of 7 registries used, show all original rules.

1407

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Check minimum number of events None

1407

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Include endpoints None

1407

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Remove individuals based on genotype QC

1368

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MACULAR_HOLE

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35

Summary Statistics

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Key figures

All Female Male
Number of individuals 1368 817 551
Unadjusted prevalence (%) 0.33 0.35 0.30
Mean age at first event (years) 70.23 68.71 72.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 5.66 [3.34, 9.59] 1.2e-10 110
15 years 0.01 2.01 [1.13, 3.57] 1.7e-2 39
5 years 0.01 5.12 [3.30, 7.94] 3.1e-13 56
1 year 0.00 5.87 [3.21, 10.71] 8.6e-9 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 3

Survival analyses between endpoints

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Plot

before Macular hole
after Macular hole

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Macular hole

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Endpoint not on priority list, no data to show.