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Other and unspecified acute skin changes due to ultraviolet radiation

DOID EFO MESH SNOMED Endpoint Browser PheWeb

L12_OTHACUSKINSUNNAS

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L56.8, L56.9
Hospital discharge: ICD-9 6927
Hospital discharge: ICD-8 6928
Hospital discharge: excluded ICD-9 6927F
Cause of death: ICD-10 L56.8, L56.9
Cause of death: ICD-9 6927
Cause of death: ICD-8 6928
Cause of death: excluded ICD-9 6927F

2 out of 7 registries used, show all original rules.

800

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Check minimum number of events None

800

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Include endpoints None

800

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Remove individuals based on genotype QC

782

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L12_OTHACUSKINSUNNAS

Control definitions

Control exclude L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 782 336 446
Unadjusted prevalence (%) 0.19 0.15 0.25
Mean age at first event (years) 40.61 40.36 40.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.90 [1.29, 2.81] 1.1e-3 167
15 years 0.01 1.23 [0.88, 1.72] 2.3e-1 69
5 years 0.00 1.77 [1.16, 2.69] 7.6e-3 32
1 year 0.00 2.96 [1.52, 5.73] 1.3e-3 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_OTHACUSKINSUNNAS – Other and unspecified acute skin changes due to ultraviolet radiation
GWS hits:

Survival analyses between endpoints

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Plot

before Other and unspecified acute skin changes due to ultraviolet radiation
after Other and unspecified acute skin changes due to ultraviolet radiation

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Drugs most likely to be purchased after Other and unspecified acute skin changes due to ultraviolet radiation

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Endpoint not on priority list, no data to show.