Hypertrophic scar

L12_HYPETROPHICSCAR

osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L91.0
Hospital discharge: ICD-9 7014B
Hospital discharge: ICD-8 70130
Cause of death: ICD-10 L91.0
Cause of death: ICD-9 7014B
Cause of death: ICD-8 70130

2 out of 7 registries used, show all original rules.

1719

diagram downward connector

Check minimum number of events None

1719

diagram downward connector

Include endpoints None

1719

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

1641

diagram downward connector
L12_HYPETROPHICSCAR

Control definitions

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L91
Name in latin Cicatrix cheloides

Summary Statistics

Key figures

All Female Male
Number of individuals 1641 1200 441
Unadjusted prevalence (%) 0.40 0.52 0.24
Mean age at first event (years) 40.19 38.61 44.52

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.41 [0.46, 4.33] 5.5e-1 76
15 years 0.01 1.11 [0.47, 2.63] 8.1e-1 32
5 years 0.00 2.37 [1.15, 4.88] 2.0e-2 18
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_HYPETROPHICSCAR – Hypertrophic scar
GWS hits: 4

Survival analyses between endpoints

Plot

before Hypertrophic scar
after Hypertrophic scar

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertrophic scar