Erythema multiforme


erythema multiforme: Erythema multiforme (EM) refers to a group ofhypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus , suggesting an immunologic process initiated by the virus. In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics. In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome . The most severe of the three is toxic epidermal necrolysis (TEN).

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L51
Hospital discharge: ICD-9 6951A|6951B|6951C
Hospital discharge: ICD-8 69510
Cause of death: ICD-10 L51
Cause of death: ICD-9 6951A|6951B|6951C
Cause of death: ICD-8 69510

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions


Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L50-L54
Name in latin Erythema multiforme

Summary Statistics

Key figures

All Female Male
Number of individuals 668 409 259
Unadjusted prevalence (%) 0.16 0.18 0.14
Mean age at first event (years) 47.39 45.68 50.08


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.55 [0.71, 3.41] 2.7e-1 84
15 years 0.01 1.02 [0.49, 2.13] 9.6e-1 31
5 years 0.00 1.87 [0.61, 5.70] 2.7e-1 24
1 year 0.00 4.74 [1.54, 14.60] 6.7e-3 11

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: L12_ERYTHEMAMULTIF – Erythema multiforme
GWS hits:

Survival analyses between endpoints


before Erythema multiforme
after Erythema multiforme

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Drugs most likely to be purchased after Erythema multiforme

Endpoint not on priority list, no data to show.