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Actinic keratosis

DOID EFO MESH SNOMED Endpoint Browser PheWeb

L12_ACTINKERA

actinic keratosis: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L57.0
Hospital discharge: ICD-9 7020A
Hospital discharge: ICD-8 70200
Cause of death: ICD-10 L57.0
Cause of death: ICD-9 7020A
Cause of death: ICD-8 70200

2 out of 7 registries used, show all original rules.

12445

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Check minimum number of events None

12445

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Include endpoints None

12445

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Remove individuals based on genotype QC

12094

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L12_ACTINKERA

Control definitions

Control exclude L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L57
Name in latin Keratosis actinica

Summary Statistics

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Key figures

All Female Male
Number of individuals 12094 6122 5972
Unadjusted prevalence (%) 2.94 2.66 3.29
Mean age at first event (years) 72.00 70.98 73.05

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.49 [2.09, 2.97] 2.5e-24 1576
15 years 0.01 1.29 [1.10, 1.51] 2.0e-3 712
5 years 0.00 2.40 [2.09, 2.76] 8.8e-35 629
1 year 0.00 2.38 [1.93, 2.94] 5.7e-16 134

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_ACTINKERA – Actinic keratosis
GWS hits: 36

Survival analyses between endpoints

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Plot

before Actinic keratosis
after Actinic keratosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Actinic keratosis

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Endpoint not on priority list, no data to show.