≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Gastro-oesophageal reflux disease

DOID EFO MESH SNOMED Endpoint Browser PheWeb

K11_REFLUX

gastroesophageal reflux disease: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K21
Hospital discharge: ICD-9 5301A
Cause of death: ICD-10 K21
Cause of death: ICD-9 5301A

2 out of 7 registries used, show all original rules.

29950

diagram downward connector

Check minimum number of events None

29950

diagram downward connector

Include endpoints None

29950

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

28858

diagram downward connector
K11_REFLUX

Control definitions

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Morbus refluxualis gastro-oesophageus

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 28858 16865 11993
Unadjusted prevalence (%) 7.00 7.32 6.60
Mean age at first event (years) 54.74 53.63 56.31

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.01 [1.74, 2.32] 6.7e-21 2679
15 years 0.01 1.38 [1.20, 1.57] 2.6e-6 1230
5 years 0.00 2.36 [2.08, 2.69] 7.0e-39 683
1 year 0.00 5.15 [4.38, 6.06] 3.6e-87 281

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: K11_REFLUX – Gastro-oesophageal reflux disease
GWS hits: 1

Survival analyses between endpoints

↥

Plot

before Gastro-oesophageal reflux disease
after Gastro-oesophageal reflux disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Gastro-oesophageal reflux disease

↥

Endpoint not on priority list, no data to show.