Irritable bowel syndrome

K11_IBS

irritable bowel syndrome: Gastrointestinal symptoms characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K58
Hospital discharge: ICD-9 5641
Hospital discharge: ICD-8 56419
Cause of death: ICD-10 K58
Cause of death: ICD-9 5641
Cause of death: ICD-8 56419

2 out of 7 registries used, show all original rules.

10705

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Check minimum number of events None

10705

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Include endpoints None

10705

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Remove individuals based on genotype QC

10329

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K11_IBS

Control definitions

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K55-K63
Name in latin Syndroma intestini irritabilis

Summary Statistics

Key figures

All Female Male
Number of individuals 10329 7632 2697
Unadjusted prevalence (%) 2.51 3.31 1.48
Mean age at first event (years) 48.86 48.08 51.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.53 [1.13, 2.08] 6.6e-3 626
15 years 0.01 1.05 [0.79, 1.38] 7.5e-1 294
5 years 0.00 1.62 [1.26, 2.08] 1.6e-4 138
1 year 0.00 2.86 [2.01, 4.05] 3.9e-9 46

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_IBS – Irritable bowel syndrome
GWS hits:

Survival analyses between endpoints

Plot

before Irritable bowel syndrome
after Irritable bowel syndrome

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Irritable bowel syndrome

Endpoint not on priority list, no data to show.