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Diaphragmatic hernia

DOID EFO MESH Endpoint Browser PheWeb

K11_DIAHER

congenital diaphragmatic hernia: Congenital diaphragmatic hernia (CDH) is a posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K44
Hospital discharge: ICD-9 5513|5523|5533
Hospital discharge: ICD-8 5513
Cause of death: ICD-10 K44
Cause of death: ICD-9 5513|5523|5533
Cause of death: ICD-8 5513

2 out of 7 registries used, show all original rules.

13361

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Check minimum number of events None

13361

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Include endpoints None

13361

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Remove individuals based on genotype QC

12886

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K11_DIAHER

Control definitions

Control exclude K11_HERNIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K40-K46
Name in latin Hernia diaphragmatica

Summary Statistics

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Key figures

All Female Male
Number of individuals 12886 7650 5236
Unadjusted prevalence (%) 3.13 3.32 2.88
Mean age at first event (years) 60.44 60.01 61.08

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.58 [2.09, 3.17] 3.9e-19 1632
15 years 0.01 1.45 [1.22, 1.73] 3.3e-5 683
5 years 0.00 3.13 [2.70, 3.63] 2.8e-52 533
1 year 0.00 6.30 [5.25, 7.57] 9.6e-87 211

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_DIAHER – Diaphragmatic hernia
GWS hits: 10

Survival analyses between endpoints

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Plot

before Diaphragmatic hernia
after Diaphragmatic hernia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diaphragmatic hernia

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