Diaphragmatic hernia

K11_DIAHER

congenital diaphragmatic hernia: Congenital diaphragmatic hernia (CDH) is a posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K44
Hospital discharge: ICD-9 5513|5523|5533
Hospital discharge: ICD-8 5513
Cause of death: ICD-10 K44
Cause of death: ICD-9 5513|5523|5533
Cause of death: ICD-8 5513

2 out of 7 registries used, show all original rules.

13361

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Check minimum number of events None

13361

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Include endpoints None

13361

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Remove individuals based on genotype QC

12886

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K11_DIAHER

Control definitions

Control exclude K11_HERNIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K40-K46
Name in latin Hernia diaphragmatica

Summary Statistics

Key figures

All Female Male
Number of individuals 12886 7650 5236
Unadjusted prevalence (%) 3.13 3.32 2.88
Mean age at first event (years) 60.44 60.01 61.08

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.58 [2.09, 3.17] 3.9e-19 1632
15 years 0.01 1.45 [1.22, 1.73] 3.3e-5 683
5 years 0.00 3.13 [2.70, 3.63] 2.8e-52 533
1 year 0.00 6.30 [5.25, 7.57] 9.6e-87 211

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_DIAHER – Diaphragmatic hernia
GWS hits: 10

Survival analyses between endpoints

Plot

before Diaphragmatic hernia
after Diaphragmatic hernia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diaphragmatic hernia