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Coeliac disease

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K11_COELIAC

celiac disease: An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K90.0
Hospital discharge: ICD-9 5790A
Cause of death: ICD-10 K90.0
Cause of death: ICD-9 5790A

2 out of 7 registries used, show all original rules.

4217

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Check minimum number of events None

4217

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Include endpoints None

4217

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Remove individuals based on genotype QC

4115

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K11_COELIAC

Control definitions

Control exclude K11_OTHDIG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K90
Name in latin Coeliacia

Summary Statistics

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Key figures

All Female Male
Number of individuals 4115 2747 1368
Unadjusted prevalence (%) 1.00 1.19 0.75
Mean age at first event (years) 46.28 43.80 51.26

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.25 [1.57, 3.22] 8.9e-6 305
15 years 0.01 1.67 [1.23, 2.26] 9.1e-4 145
5 years 0.00 2.61 [1.88, 3.64] 1.1e-8 70
1 year 0.00 6.41 [4.22, 9.74] 3.5e-18 32

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_COELIAC – Coeliac disease
GWS hits: 23

Survival analyses between endpoints

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Plot

before Coeliac disease
after Coeliac disease

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Drugs most likely to be purchased after Coeliac disease

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Endpoint not on priority list, no data to show.