Hypersensitivity pneumonitis due to organic dust

J10_HYPERSPNEUMONI

extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J67
Hospital discharge: ICD-9 495
Cause of death: ICD-10 J67
Cause of death: ICD-9 495

2 out of 7 registries used, show all original rules.

485

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Check minimum number of events None

485

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Include endpoints None

485

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Remove individuals based on genotype QC

476

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J10_HYPERSPNEUMONI

Control definitions

Control exclude J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J60-J70
Name in latin Pneumonitis/alveolitis hypersensitiva e pulvere organico

Summary Statistics

Key figures

All Female Male
Number of individuals 476 246 230
Unadjusted prevalence (%) 0.12 0.11 0.13
Mean age at first event (years) 46.22 44.76 47.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: 1

Survival analyses between endpoints

Plot

before Hypersensitivity pneumonitis due to organic dust
after Hypersensitivity pneumonitis due to organic dust

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Drugs most likely to be purchased after Hypersensitivity pneumonitis due to organic dust

Endpoint not on priority list, no data to show.