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Rheumatic fever without mention of heart involvement

DOID EFO MESH SNOMED Endpoint Browser PheWeb

I9_RHEUFEVWITHOUTHEART

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9
Hospital discharge: ICD-9 390
Hospital discharge: ICD-8 390
Cause of death: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9
Cause of death: ICD-9 390
Cause of death: ICD-8 390

2 out of 7 registries used, show all original rules.

104

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Check minimum number of events None

104

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Include endpoints None

104

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Remove individuals based on genotype QC

103

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I9_RHEUFEVWITHOUTHEART

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 103 55 48
Unadjusted prevalence (%) 0.03 0.02 0.03
Mean age at first event (years) 33.66 32.95 34.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement
GWS hits:

Survival analyses between endpoints

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Plot

before Rheumatic fever without mention of heart involvement
after Rheumatic fever without mention of heart involvement

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Drugs most likely to be purchased after Rheumatic fever without mention of heart involvement

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Endpoint not on priority list, no data to show.