Hypertrophic cardiomyopathy

I9_HYPERTROCARDMYOP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I42.1, I42.2
Cause of death: ICD-10 I42.1, I42.2

2 out of 7 registries used, show all original rules.

1172

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Check minimum number of events None

1172

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Include endpoints None

1172

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Remove individuals based on genotype QC

1125

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I9_HYPERTROCARDMYOP

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 1125 455 670
Unadjusted prevalence (%) 0.27 0.20 0.37
Mean age at first event (years) 57.97 55.86 59.41

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.49 [1.60, 7.62] 1.7e-3 237
15 years 0.01 2.03 [1.14, 3.59] 1.6e-2 84
5 years 0.01 5.43 [3.51, 8.38] 2.4e-14 71
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_HYPERTROCARDMYOP – Hypertrophic cardiomyopathy
GWS hits: 21

Survival analyses between endpoints

Plot

before Hypertrophic cardiomyopathy
after Hypertrophic cardiomyopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertrophic cardiomyopathy

Endpoint not on priority list, no data to show.