Cerebral amyloid angiopathy

I9_CEREBAMY

cerebral amyloid angiopathy: Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I68.0*, I68.0*E85.9
Cause of death: ICD-10 I68.0*, I68.0*E85.9

2 out of 7 registries used, show all original rules.

88

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Check minimum number of events None

88

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Include endpoints None

88

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Remove individuals based on genotype QC

83

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I9_CEREBAMY

Control definitions

Control exclude I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 83 31 52
Unadjusted prevalence (%) 0.02 0.01 0.03
Mean age at first event (years) 70.72 67.16 72.84

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_CEREBAMY – Cerebral amyloid angiopathy
GWS hits: 1

Survival analyses between endpoints

Plot

before Cerebral amyloid angiopathy
after Cerebral amyloid angiopathy

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Drugs most likely to be purchased after Cerebral amyloid angiopathy

Endpoint not on priority list, no data to show.