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Sensorineural hearing loss

DOID EFO MESH SNOMED Endpoint Browser PheWeb

H8_HL_SEN_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H90.3, H90.4, H90.5
Hospital discharge: ICD-9 3891
Cause of death: ICD-10 H90.3, H90.4, H90.5
Cause of death: ICD-9 3891

2 out of 7 registries used, show all original rules.

36647

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Check minimum number of events None

36647

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Include endpoints None

36647

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Remove individuals based on genotype QC

35488

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H8_HL_SEN_NAS

Control definitions

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 35488 16663 18825
Unadjusted prevalence (%) 8.61 7.24 10.36
Mean age at first event (years) 64.50 62.60 66.19

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.87 [1.63, 2.15] 6.2e-19 5448
15 years 0.01 1.24 [1.11, 1.38] 1.4e-4 2702
5 years 0.00 2.07 [1.89, 2.27] 6.8e-57 1731
1 year 0.00 2.70 [2.37, 3.08] 2.9e-50 444

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 31

Survival analyses between endpoints

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Plot

before Sensorineural hearing loss
after Sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sensorineural hearing loss

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Endpoint not on priority list, no data to show.