Disorders of optic nerve and visual pathways

H7_OPTNERVE

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H46-H48
Cause of death: ICD-10 H46-H48

2 out of 7 registries used, show all original rules.

2853

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Check minimum number of events None

2853

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Remove individuals based on genotype QC

2991

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H7_OPTNERVE

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 2991 1962 1029
Unadjusted prevalence (%) 0.73 0.85 0.57
Mean age at first event (years) 45.02 42.18 50.44

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.63 [1.77, 3.92] 1.7e-6 294
15 years 0.01 1.45 [0.97, 2.17] 6.8e-2 113
5 years 0.00 2.57 [1.61, 4.09] 7.6e-5 69
1 year 0.00 9.30 [5.80, 14.89] 1.8e-20 46

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_OPTNERVE – Disorders of optic nerve and visual pathways
GWS hits:

Survival analyses between endpoints

Plot

before Disorders of optic nerve and visual pathways
after Disorders of optic nerve and visual pathways

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Drugs most likely to be purchased after Disorders of optic nerve and visual pathways

Endpoint not on priority list, no data to show.