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Disorders of globe

DOID EFO MESH SNOMED Endpoint Browser PheWeb

H7_GLOBE

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

728

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Remove individuals based on genotype QC

708

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H7_GLOBE

Control definitions

Control exclude H7_VITREOUS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 708 367 341
Unadjusted prevalence (%) 0.17 0.16 0.19
Mean age at first event (years) 57.72 57.40 58.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.44 [0.59, 3.51] 4.3e-1 180
15 years 0.01 1.23 [0.67, 2.25] 5.0e-1 85
5 years 0.00 2.19 [1.41, 3.40] 4.8e-4 52
1 year 0.00 3.99 [2.31, 6.91] 7.5e-7 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_GLOBE – Disorders of globe
GWS hits:

Survival analyses between endpoints

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Plot

before Disorders of globe
after Disorders of globe

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Drugs most likely to be purchased after Disorders of globe

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Endpoint not on priority list, no data to show.