Background retinopathy and retinal vascular changes

DOID EFO MESH SNOMED Endpoint Browser PheWeb

H7_BCKRNDRETINOPAT

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.0

Hospital discharge: ICD-9 3621|3624A

Hospital discharge: ICD-8 36701|37705|37709|37712

Cause of death: ICD-10 H35.0

Cause of death: ICD-9 3621|3624A

Cause of death: ICD-8 36701|37705|37709|37712

2 out of 7 registries used, show all original rules.

600

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Check minimum number of events None

600

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Include endpoints None

600

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Remove individuals based on genotype QC

576

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H7_BCKRNDRETINOPAT

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF6

Parent code in ICD-10 H35

Name in latin Retinopathia recessualis et commutationes vasculares retinae

NAME	H7_BCKRNDRETINOPAT
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H350
HD_ICD_9	3621\|3624A
HD_ICD_8	36701\|37705\|37709\|37712
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H350
COD_ICD_9	3621\|3624A
COD_ICD_8	36701\|37705\|37709\|37712
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Background retinopathy and retinal vascular changes based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	576	275	301
Unadjusted prevalence (%)	0.14	0.12	0.17
Mean age at first event (years)	55.66	55.93	55.42

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	5.07 [3.32, 7.73]	5.1e-14	97
15 years	0.02	2.65 [1.66, 4.24]	4.6e-5	45
5 years	0.00	3.28 [1.58, 6.79]	1.4e-3	31
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes
GWS hits: 1

Survival analyses between endpoints

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Plot

before Background retinopathy and retinal vascular changes
after Background retinopathy and retinal vascular changes

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Table

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Drugs most likely to be purchased after Background retinopathy and retinal vascular changes

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Endpoint not on priority list, no data to show.