Postpolio syndrome

G6_POSTPOLIO

postpoliomyelitis syndrome: Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis (see this term), 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G14
Hospital discharge: ICD-9 138
Hospital discharge: ICD-8 4499
Cause of death: ICD-10 G14
Cause of death: ICD-9 138
Cause of death: ICD-8 4499

2 out of 7 registries used, show all original rules.

67

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Check minimum number of events None

67

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Include endpoints None

67

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Remove individuals based on genotype QC

63

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G6_POSTPOLIO

Control definitions

Control exclude G6_NEUATR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 63 36 27
Unadjusted prevalence (%) 0.02 0.02 0.01
Mean age at first event (years) 49.95 47.62 53.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_POSTPOLIO – Postpolio syndrome
GWS hits:

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Postpolio syndrome

Endpoint not on priority list, no data to show.