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Other and unspecified polyneuropathies, also in other diseases

DOID EFO MESH SNOMED Endpoint Browser PheWeb

G6_POLYOTHUNS

chronic inflammatory demyelinating polyradiculoneuropathy: A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G61.1#, G61.8, G61.9, G62.8, G62.9, G63*, G63.0*B02.29
Hospital discharge: ICD-9 357[8-9]
Hospital discharge: ICD-8 3540[8-9]
Cause of death: ICD-10 G61.1#, G61.8, G61.9, G62.8, G62.9, G63*, G63.0*B02.29
Cause of death: ICD-9 357[8-9]
Cause of death: ICD-8 3540[8-9]

2 out of 7 registries used, show all original rules.

6242

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Check minimum number of events None

6242

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Include endpoints None

6242

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Remove individuals based on genotype QC

6027

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G6_POLYOTHUNS

Control definitions

Control exclude G6_POLYNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 6027 2306 3721
Unadjusted prevalence (%) 1.46 1.00 2.05
Mean age at first event (years) 62.02 59.59 63.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 2.79 [1.99, 3.90] 2.2e-9 1166
15 years 0.01 1.76 [1.38, 2.24] 5.2e-6 518
5 years 0.00 3.40 [2.83, 4.08] 1.0e-38 366
1 year 0.00 7.74 [6.25, 9.59] 5.5e-78 168

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_POLYOTHUNS – Other and unspecified polyneuropathies, also in other diseases
GWS hits: 2

Survival analyses between endpoints

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Plot

before Other and unspecified polyneuropathies, also in other diseases
after Other and unspecified polyneuropathies, also in other diseases

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Drugs most likely to be purchased after Other and unspecified polyneuropathies, also in other diseases

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Endpoint not on priority list, no data to show.