Other inherited muscular atrophy

G6_OTHINMUSC

amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G12.1
Hospital discharge: ICD-9 3351A
Cause of death: ICD-10 G12.1
Cause of death: ICD-9 3351A

2 out of 7 registries used, show all original rules.

51

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Check minimum number of events None

51

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Include endpoints None

51

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Remove individuals based on genotype QC

50

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G6_OTHINMUSC

Control definitions

Control exclude G6_NEUATR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G12
Name in latin Alia atrophia musculorum spinalis congenita

Summary Statistics

Key figures

All Female Male
Number of individuals 50 22 28
Unadjusted prevalence (%) 0.01 0.01 0.02
Mean age at first event (years) 48.90 45.77 51.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_OTHINMUSC – Other inherited muscular atrophy
GWS hits:

Survival analyses between endpoints

Plot

before Other inherited muscular atrophy
after Other inherited muscular atrophy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other inherited muscular atrophy

Endpoint not on priority list, no data to show.