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Myasthenia gravis

DOID EFO MESH SNOMED Endpoint Browser PheWeb

G6_MYASTHENIA

Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G70.0#
Hospital discharge: ICD-9 3580
Hospital discharge: ICD-8 7330
Cause of death: ICD-10 G70.0#
Cause of death: ICD-9 3580
Cause of death: ICD-8 7330
KELA reimbursements: KELA codes 108

3 out of 7 registries used, show all original rules.

480

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Check minimum number of events None

480

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Include endpoints None

480

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Remove individuals based on genotype QC

461

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G6_MYASTHENIA

Control definitions

Control exclude G6_MYONEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G70

Summary Statistics

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Key figures

All Female Male
Number of individuals 461 246 215
Unadjusted prevalence (%) 0.11 0.11 0.12
Mean age at first event (years) 52.63 46.91 59.18

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_MYASTHENIA – Myasthenia gravis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Myasthenia gravis
after Myasthenia gravis

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Drugs most likely to be purchased after Myasthenia gravis

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Endpoint not on priority list, no data to show.