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Other and unspecified degenerative diseases of nervous system

DOID EFO MESH SNOMED Endpoint Browser PheWeb

G6_DEGENOTH

Lewy body dementia: A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G31.8, G31.9, G32*
Hospital discharge: ICD-9 331[8-9]
Hospital discharge: ICD-8 32303
Cause of death: ICD-10 G31.8, G31.9, G32*
Cause of death: ICD-9 331[8-9]
Cause of death: ICD-8 32303

2 out of 7 registries used, show all original rules.

645

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Check minimum number of events None

645

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Include endpoints None

645

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Remove individuals based on genotype QC

625

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G6_DEGENOTH

Control definitions

Control exclude G6_NEURODEG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 625 233 392
Unadjusted prevalence (%) 0.15 0.10 0.22
Mean age at first event (years) 67.65 64.16 69.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_DEGENOTH – Other and unspecified degenerative diseases of nervous system
GWS hits: 2

Survival analyses between endpoints

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Plot

before Other and unspecified degenerative diseases of nervous system
after Other and unspecified degenerative diseases of nervous system

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Drugs most likely to be purchased after Other and unspecified degenerative diseases of nervous system

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Endpoint not on priority list, no data to show.