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Alzheimer disease

DOID EFO MESH SNOMED Endpoint Browser PheWeb

G6_ALZHEIMER

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G30
Hospital discharge: ICD-9 3310
Cause of death: ICD-10 G30
Cause of death: ICD-9 3310

2 out of 7 registries used, show all original rules.

10889

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Check minimum number of events None

10889

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Include endpoints None

10889

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Remove individuals based on genotype QC

10520

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G6_ALZHEIMER

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G30-G32
Name in latin Morbus Alzheimer

Similar endpoints

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List of similar endpoints to Alzheimer disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 10520 4620 5900
Unadjusted prevalence (%) 2.55 2.01 3.25
Mean age at first event (years) 79.35 79.30 79.39

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.21 10.14 [8.45, 12.18] <1e-100 6141
15 years 0.00 0.19 [0.06, 0.54] 1.8e-3 1537
5 years 0.01 7.46 [6.83, 8.15] <1e-100 2670
1 year 0.01 18.73 [16.98, 20.66] <1e-100 1919

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_ALZHEIMER – Alzheimer disease
GWS hits: 16

Survival analyses between endpoints

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Plot

before Alzheimer disease
after Alzheimer disease

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Drugs most likely to be purchased after Alzheimer disease

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