Motor neuron disease

G6_ALS

motor neuron disease: A disease involving the motor neuron.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G12.2
Hospital discharge: ICD-9 3352A
Hospital discharge: ICD-8 348[0-1]|34821
Cause of death: ICD-10 G12.2
Cause of death: ICD-9 3352A
Cause of death: ICD-8 348[0-1]|34821

2 out of 7 registries used, show all original rules.

545

diagram downward connector

Check minimum number of events None

545

diagram downward connector

Include endpoints None

545

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

531

diagram downward connector
G6_ALS

Control definitions

Control exclude F5_PSYCH, NEURODIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G12
Name in latin Morbus motoneuronalis

Summary Statistics

Key figures

All Female Male
Number of individuals 531 204 327
Unadjusted prevalence (%) 0.13 0.09 0.18
Mean age at first event (years) 65.00 64.02 65.61

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_ALS – Motor neuron disease
GWS hits: 4

Survival analyses between endpoints

Plot

before Motor neuron disease
after Motor neuron disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Motor neuron disease