Motor neuron disease

DOID EFO MESH SNOMED Endpoint Browser PheWeb

G6_ALS

motor neuron disease: A disease involving the motor neuron.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G12.2

Hospital discharge: ICD-9 3352A

Hospital discharge: ICD-8 348[0-1]|34821

Cause of death: ICD-10 G12.2

Cause of death: ICD-9 3352A

Cause of death: ICD-8 348[0-1]|34821

2 out of 7 registries used, show all original rules.

545

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Check minimum number of events None

545

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Include endpoints None

545

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Remove individuals based on genotype QC

531

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G6_ALS

Control definitions

Control exclude F5_PSYCH, NEURODIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G12

Name in latin Morbus motoneuronalis

NAME	G6_ALS
CONTROL_EXCLUDE	F5_PSYCH\|NEURODIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G122
HD_ICD_9	3352A
HD_ICD_8	348[0-1]\|34821
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G122
COD_ICD_9	3352A
COD_ICD_8	348[0-1]\|34821
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Motor neuron disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	531	204	327
Unadjusted prevalence (%)	0.13	0.09	0.18
Mean age at first event (years)	65.00	64.02	65.61

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_ALS – Motor neuron disease
GWS hits: 4

Survival analyses between endpoints

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Plot

before Motor neuron disease
after Motor neuron disease

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Table

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Drugs most likely to be purchased after Motor neuron disease

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