Focal epilepsy, mode (most common among epilepsy diagnosis)

DOID EFO MESH SNOMED Endpoint Browser PheWeb

FE_MODE

partial epilepsy: A seizure caused by a localized disorder.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Check mode of ICD-10 codes: %3453, %345[4-5], %G403

Hospital Discharge: ICD-10 G40.3

Hospital discharge: ICD-9 %345[4-5]

Hospital discharge: ICD-8 %3453

Cause of death: ICD-10 G40.3

Cause of death: ICD-9 %345[4-5]

Cause of death: ICD-8 %3453

2 out of 7 registries used, show all original rules.

1446

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Check minimum number of events None

1446

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Include endpoints None

1446

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Remove individuals based on genotype QC

1390

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FE_MODE

Control definitions

Control exclude G6_EPLEPSY

Extra metadata

First used in FinnGen datafreeze DF3

NAME	FE_MODE
CONTROL_EXCLUDE	G6_EPLEPSY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	%G403
HD_ICD_9	%345[4-5]
HD_ICD_8	%3453
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	%G403
COD_ICD_9	%345[4-5]
COD_ICD_8	%3453
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Focal epilepsy, mode (most common among epilepsy diagnosis) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1390	828	562
Unadjusted prevalence (%)	0.34	0.36	0.31
Mean age at first event (years)	27.49	25.03	31.12

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	2.27 [1.28, 4.03]	5.1e-3	174
15 years	0.01	1.55 [1.02, 2.36]	3.9e-2	69
5 years	0.00	1.90 [1.24, 2.91]	3.3e-3	28
1 year	0.00	4.59 [2.53, 8.33]	5.3e-7	13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: FE_MODE – Focal epilepsy, mode (most common among epilepsy diagnosis)
GWS hits:

Survival analyses between endpoints

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Plot

before Focal epilepsy, mode (most common among epilepsy diagnosis)
after Focal epilepsy, mode (most common among epilepsy diagnosis)

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Table

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Drugs most likely to be purchased after Focal epilepsy, mode (most common among epilepsy diagnosis)

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Endpoint not on priority list, no data to show.