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Alcohol dependence

DOID EFO MESH SNOMED Endpoint Browser PheWeb

F5_ALCOHOL_DEPENDENCE

alcohol dependence: Physical and psychological dependence on alcohol.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F10.2
Hospital discharge: ICD-9 303
Hospital discharge: ICD-8 303
Cause of death: ICD-10 F10.2
Cause of death: ICD-9 303
Cause of death: ICD-8 303

2 out of 7 registries used, show all original rules.

11012

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Check minimum number of events None

11012

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Include endpoints None

11012

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Remove individuals based on genotype QC

10707

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F5_ALCOHOL_DEPENDENCE

Control definitions

Control exclude F5_SUBSTANCE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 F10

Summary Statistics

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Key figures

All Female Male
Number of individuals 10707 2919 7788
Unadjusted prevalence (%) 2.60 1.27 4.29
Mean age at first event (years) 43.70 41.35 44.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.37 [2.72, 4.17] 7.7e-29 2672
15 years 0.02 2.43 [2.09, 2.83] 2.4e-30 1062
5 years 0.01 4.15 [3.66, 4.72] <1e-100 545
1 year 0.00 15.10 [13.02, 17.51] <1e-100 383

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_ALCOHOL_DEPENDENCE – Alcohol dependence
GWS hits: 6

Survival analyses between endpoints

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Plot

before Alcohol dependence
after Alcohol dependence

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alcohol dependence

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Endpoint not on priority list, no data to show.