Eosinophilic disease (BM)

ESOSINOPHIL_DISEASE

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D72.1
Hospital discharge: ICD-9 2883
Cause of death: ICD-10 D72.1
Cause of death: ICD-9 2883

2 out of 7 registries used, show all original rules.

461

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Check minimum number of events None

461

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Include endpoints None

461

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Remove individuals based on genotype QC

441

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ESOSINOPHIL_DISEASE

Control definitions

Control exclude ASTHMA_EXCL

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 D72
Name in latin Eosinophilia

Summary Statistics

Key figures

All Female Male
Number of individuals 441 239 202
Unadjusted prevalence (%) 0.11 0.10 0.11
Mean age at first event (years) 54.47 51.15 58.41

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ESOSINOPHIL_DISEASE – Eosinophilic disease (BM)
GWS hits:

Survival analyses between endpoints

Plot

before Eosinophilic disease (BM)
after Eosinophilic disease (BM)

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Drugs most likely to be purchased after Eosinophilic disease (BM)

Endpoint not on priority list, no data to show.