Thyrotoxicosis with toxic single thyroid nodule

E4_THYTOXNOD

Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E05.1
Hospital discharge: ICD-9 2421
Cause of death: ICD-10 E05.1
Cause of death: ICD-9 2421

2 out of 7 registries used, show all original rules.

249

diagram downward connector

Check minimum number of events None

249

diagram downward connector

Include endpoints None

249

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

246

diagram downward connector
E4_THYTOXNOD

Control definitions

Control exclude THYROTOXICOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma uninodulari

Summary Statistics

Key figures

All Female Male
Number of individuals 246 204 42
Unadjusted prevalence (%) 0.06 0.09 0.02
Mean age at first event (years) 51.73 49.42 62.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1

Survival analyses between endpoints

Plot

before Thyrotoxicosis with toxic single thyroid nodule
after Thyrotoxicosis with toxic single thyroid nodule

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Thyrotoxicosis with toxic single thyroid nodule

Endpoint not on priority list, no data to show.