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Thyrotoxicosis with toxic multinodular goitre

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_THYTOXGOITMULT

Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E05.2
Hospital discharge: ICD-9 2422
Hospital discharge: ICD-8 2421
Cause of death: ICD-10 E05.2
Cause of death: ICD-9 2422
Cause of death: ICD-8 2421

2 out of 7 registries used, show all original rules.

1758

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Check minimum number of events None

1758

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Include endpoints None

1758

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Remove individuals based on genotype QC

1717

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E4_THYTOXGOITMULT

Control definitions

Control exclude THYROTOXICOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma multinodulari

Summary Statistics

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Key figures

All Female Male
Number of individuals 1717 1387 330
Unadjusted prevalence (%) 0.42 0.60 0.18
Mean age at first event (years) 57.79 56.55 63.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 2.92 [2.21, 3.85] 3.3e-14 209
15 years 0.01 1.39 [1.04, 1.86] 2.5e-2 77
5 years 0.00 2.49 [1.77, 3.51] 1.9e-7 50
1 year 0.00 4.88 [2.94, 8.08] 8.1e-10 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 16

Survival analyses between endpoints

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Plot

before Thyrotoxicosis with toxic multinodular goitre
after Thyrotoxicosis with toxic multinodular goitre

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Drugs most likely to be purchased after Thyrotoxicosis with toxic multinodular goitre

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Endpoint not on priority list, no data to show.