Autoimmune thyroiditis

E4_THYROIDITAUTOIM

autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E06.3
Hospital discharge: ICD-9 2452
Cause of death: ICD-10 E06.3
Cause of death: ICD-9 2452

2 out of 7 registries used, show all original rules.

551

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Check minimum number of events None

551

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Include endpoints None

551

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Remove individuals based on genotype QC

539

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E4_THYROIDITAUTOIM

Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E06
Name in latin Thyreoiditis autoimmunis

Summary Statistics

Key figures

All Female Male
Number of individuals 539 465 74
Unadjusted prevalence (%) 0.13 0.20 0.04
Mean age at first event (years) 41.93 41.21 46.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.60 [1.18, 10.94] 2.4e-2 27
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis
GWS hits: 2

Survival analyses between endpoints

Plot

before Autoimmune thyroiditis
after Autoimmune thyroiditis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Autoimmune thyroiditis

Endpoint not on priority list, no data to show.