Other and/or unspecified nontoxic goitre

E4_GOITRENAS

goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E04.8, E04.9
Hospital discharge: ICD-9 2419
Cause of death: ICD-10 E04.8, E04.9
Cause of death: ICD-9 2419

2 out of 7 registries used, show all original rules.

2632

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Check minimum number of events None

2632

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Include endpoints None

2632

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Remove individuals based on genotype QC

2543

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E4_GOITRENAS

Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 2543 2134 409
Unadjusted prevalence (%) 0.62 0.93 0.23
Mean age at first event (years) 54.39 53.17 60.80

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.43 [0.92, 2.23] 1.1e-1 213
15 years 0.01 0.96 [0.65, 1.43] 8.4e-1 82
5 years 0.00 2.11 [1.45, 3.07] 9.3e-5 54
1 year 0.00 4.15 [2.46, 6.98] 8.5e-8 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre
GWS hits: 16

Survival analyses between endpoints

Plot

before Other and/or unspecified nontoxic goitre
after Other and/or unspecified nontoxic goitre

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and/or unspecified nontoxic goitre

Endpoint not on priority list, no data to show.