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Nontoxic multinodular goitre

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_GOITREMULTINOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E04.2
Hospital discharge: ICD-9 2411
Hospital discharge: ICD-8 241
Cause of death: ICD-10 E04.2
Cause of death: ICD-9 2411
Cause of death: ICD-8 241

2 out of 7 registries used, show all original rules.

6924

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Check minimum number of events None

6924

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Include endpoints None

6924

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Remove individuals based on genotype QC

6699

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E4_GOITREMULTINOD

Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E04
Name in latin Struma atoxica multinodularis

Summary Statistics

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Key figures

All Female Male
Number of individuals 6699 5635 1064
Unadjusted prevalence (%) 1.63 2.45 0.59
Mean age at first event (years) 52.47 51.31 58.63

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.52 [1.21, 1.90] 3.4e-4 618
15 years 0.01 1.11 [0.90, 1.38] 3.3e-1 257
5 years 0.00 1.62 [1.27, 2.06] 9.1e-5 111
1 year 0.00 1.80 [1.16, 2.79] 8.9e-3 23

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITREMULTINOD – Nontoxic multinodular goitre
GWS hits: 44

Survival analyses between endpoints

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Plot

before Nontoxic multinodular goitre
after Nontoxic multinodular goitre

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nontoxic multinodular goitre

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Endpoint not on priority list, no data to show.