Congenital iodine-deficiency syndrome/hypothyroidism

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_CONGEIOD

thyroid disease: A disease involving the thyroid gland.

Endpoint definition

↥

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E00, E03.0, E03.1

Hospital discharge: ICD-9 243

Hospital discharge: ICD-8 243

Cause of death: ICD-10 E00, E03.0, E03.1

Cause of death: ICD-9 243

Cause of death: ICD-8 243

2 out of 7 registries used, show all original rules.

969

diagram downward connector

Check minimum number of events None

969

diagram downward connector

Include endpoints None

969

diagram downward connector

diagram downward connector

Remove individuals based on genotype QC

935

diagram downward connector

E4_CONGEIOD

Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

NAME	E4_CONGEIOD
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E00\|E03[0-1]
HD_ICD_9	243
HD_ICD_8	243
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E00\|E03[0-1]
COD_ICD_9	243
COD_ICD_8	243
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

↥

List of similar endpoints to Congenital iodine-deficiency syndrome/hypothyroidism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	935	740	195
Unadjusted prevalence (%)	0.23	0.32	0.11
Mean age at first event (years)	55.77	54.28	61.42

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	4.79 [2.23, 10.27]	5.7e-5	153
15 years	0.01	1.79 [0.81, 3.93]	1.5e-1	53
5 years	0.01	4.79 [2.93, 7.85]	4.9e-10	57
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism
GWS hits: 2

Survival analyses between endpoints

↥

Plot

before Congenital iodine-deficiency syndrome/hypothyroidism
after Congenital iodine-deficiency syndrome/hypothyroidism

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Congenital iodine-deficiency syndrome/hypothyroidism

↥

Endpoint not on priority list, no data to show.