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Idiopathic thrombocytopenic purpura

DOID EFO MESH Endpoint Browser PheWeb

D3_ITP

autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D69.3
Hospital discharge: ICD-9 2873A
Hospital discharge: ICD-8 28710
Cause of death: ICD-10 D69.3
Cause of death: ICD-9 2873A
Cause of death: ICD-8 28710

2 out of 7 registries used, show all original rules.

912

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Check minimum number of events None

912

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Include endpoints None

912

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Remove individuals based on genotype QC

882

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D3_ITP

Control definitions

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Purpura idiopathica thrombocytopenica

Summary Statistics

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Key figures

All Female Male
Number of individuals 882 461 421
Unadjusted prevalence (%) 0.21 0.20 0.23
Mean age at first event (years) 48.41 42.69 54.67

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 7.31 [4.92, 10.87] 7.3e-23 158
15 years 0.02 2.93 [1.92, 4.49] 6.6e-7 55
5 years 0.01 4.80 [2.83, 8.12] 5.2e-9 48
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits: 1

Survival analyses between endpoints

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Plot

before Idiopathic thrombocytopenic purpura
after Idiopathic thrombocytopenic purpura

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Idiopathic thrombocytopenic purpura

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Endpoint not on priority list, no data to show.