Acquired haemolytic anaemia

DOID EFO MESH SNOMED Endpoint Browser PheWeb

D3_ACQHAEMOLYTICANAEMIA

hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D59

Cause of death: ICD-10 D59

2 out of 7 registries used, show all original rules.

624

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Check minimum number of events None

624

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Include endpoints

D3_NONAIHA_DRUG

D3_NONAIHA_OTHER

D3_NOCT_HAEMOGLOBINURIA

D3_HAEMOURAEMICSDR

D3_HAEMOGLOB_OTHEXT

D3_ACQHAEMOLYTICANAEMIANAS

678

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Remove individuals based on genotype QC

654

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D3_ACQHAEMOLYTICANAEMIA

Control definitions

Control exclude D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D55-D59

Name in latin Anaemia haemolytica acquisita

NAME	D3_ACQHAEMOLYTICANAEMIA
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	D3_AIHA_DRUG\|D3_AIHA_OTHER\|D3_NONAIHA_DRUG\|D3_NONAIHA_OTHER\|D3_NOCT_HAEMOGLOBINURIA\|D3_HAEMOURAEMICSDR\|D3_HAEMOGLOB_OTHEXT\|D3_ACQHAEMOLYTICANAEMIANAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D59
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D59
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Acquired haemolytic anaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	654	321	333
Unadjusted prevalence (%)	0.16	0.14	0.18
Mean age at first event (years)	55.60	51.04	59.99

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.11	5.63 [3.09, 10.27]	1.8e-8	166
15 years	0.01	1.67 [0.86, 3.22]	1.3e-1	41
5 years	0.01	6.41 [4.02, 10.21]	6.1e-15	55
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ACQHAEMOLYTICANAEMIA – Acquired haemolytic anaemia
GWS hits: 3

Survival analyses between endpoints

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Plot

before Acquired haemolytic anaemia
after Acquired haemolytic anaemia

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Table

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Drugs most likely to be purchased after Acquired haemolytic anaemia

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Endpoint not on priority list, no data to show.