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Later onset COPD

DOID EFO MESH SNOMED Endpoint Browser PheWeb

COPD_LATER

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

not COPD_EARLY

421297

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Check pre-conditions, main-only, mode, registry filters

Pre-conditions EVENT_AGE>=65
Hospital Discharge: ICD-10 J44
Hospital discharge: ICD-9 4912
Hospital discharge: ICD-8 49104
Cause of death: ICD-10 J44
Cause of death: ICD-9 4912
Cause of death: ICD-8 49104

2 out of 7 registries used, show all original rules.

11824

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Check minimum number of events None

11824

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Include endpoints None

11824

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Remove individuals based on genotype QC

11519

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COPD_LATER

Control definitions

Control exclude COPD_EARLYANDLATER
Control pre-conditions DEATH_AGE>=65
Control conditions not COPD_EARLY

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Alii morbi obstructivi chronici pulmonum

Summary Statistics

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Key figures

All Female Male
Number of individuals 11519 2014 9505
Unadjusted prevalence (%) 2.80 0.87 5.23
Mean age at first event (years) 74.27 72.98 74.54

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.17 7.67 [6.77, 8.69] <1e-100 7004
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: COPD_LATER – Later onset COPD
GWS hits: 3

Survival analyses between endpoints

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Plot

before Later onset COPD
after Later onset COPD

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Later onset COPD

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Endpoint not on priority list, no data to show.