Chronic myeloproliferative disease

CHRONMYELOPRO

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D47.1
Cause of death: ICD-10 D47.1

2 out of 7 registries used, show all original rules.

365

diagram downward connector

Check minimum number of events None

365

diagram downward connector

Include endpoints None

365

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

354

diagram downward connector
CHRONMYELOPRO

Control definitions

Control exclude MYELOPROF

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

Key figures

All Female Male
Number of individuals 354 163 191
Unadjusted prevalence (%) 0.09 0.07 0.11
Mean age at first event (years) 63.92 62.21 65.37

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: CHRONMYELOPRO – Chronic myeloproliferative disease
GWS hits: 2

Survival analyses between endpoints

Plot

before Chronic myeloproliferative disease
after Chronic myeloproliferative disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Chronic myeloproliferative disease

Endpoint not on priority list, no data to show.