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Non-follicular lymphoma

CD2_NONFOLLICULAR_LYMPHOMA

neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 C83
Hospital discharge: ICD-9 200
Hospital discharge: excluded ICD-9 200A
Cause of death: ICD-10 C83
Cause of death: ICD-9 200
Cause of death: excluded ICD-9 200A

2 out of 7 registries used, show all original rules.

2907

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Check minimum number of events None

2907

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Include endpoints None

2907

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Remove individuals based on genotype QC

2811

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CD2_NONFOLLICULAR_LYMPHOMA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 C81-C96
Name in latin Lymphoma non-Hodgkin diffusum

Similar endpoints

List of similar endpoints to Non-follicular lymphoma based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 2811 1140 1671
Unadjusted prevalence (%) 0.68 0.50 0.92
Mean age at first event (years) 63.42 61.45 64.76

Mortality

Not a core endpoint, no data to show.

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Not a core endpoint, no data to show.

Correlations

Index endpoint: CD2_NONFOLLICULAR_LYMPHOMA – Non-follicular lymphoma
GWS hits: 1

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Non-follicular lymphoma

Endpoint not on priority list, no data to show.