Leiomyoma of uterus

CD2_BENIGN_LEIOMYOMA_UTERI

uterine fibroid: A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule

Sex only females

239906

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Check conditions None

239906

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D25
Hospital discharge: ICD-9 218
Hospital discharge: ICD-8 21899
Cause of death: ICD-10 D25
Cause of death: ICD-9 218
Cause of death: ICD-8 21899

2 out of 7 registries used, show all original rules.

35628

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Check minimum number of events None

35628

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Include endpoints None

35628

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Remove individuals based on genotype QC

34421

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CD2_BENIGN_LEIOMYOMA_UTERI

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Leiomyoma uteri

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 34421 34421 -
Unadjusted prevalence (%) 8.35 14.95 -
Mean age at first event (years) 47.16 47.16 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.46 [0.40, 0.53] 7.2e-29 2026
15 years 0.00 0.33 [0.29, 0.38] 1.3e-57 629
5 years 0.00 0.34 [0.28, 0.42] 2.2e-26 138
1 year 0.00 0.62 [0.45, 0.86] 4.3e-3 42

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: CD2_BENIGN_LEIOMYOMA_UTERI – Leiomyoma of uterus
GWS hits: 105

Survival analyses between endpoints

Plot

before Leiomyoma of uterus
after Leiomyoma of uterus

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Drugs most likely to be purchased after Leiomyoma of uterus