Asthma, unspecified (mode)

ASTHMA_NAS

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Check mode of ICD-10 codes: %J459
Hospital Discharge: ICD-10 J45.9
Cause of death: ICD-10 J45.9

2 out of 7 registries used, show all original rules.

24656

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Check minimum number of events None

24656

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Include endpoints None

24656

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Remove individuals based on genotype QC

23834

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ASTHMA_NAS

Control definitions

Control exclude J10_ASTHMA, ASTHMA_EXCL

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 23834 14677 9157
Unadjusted prevalence (%) 5.79 6.37 5.04
Mean age at first event (years) 55.65 53.27 59.48

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.11 [3.59, 4.70] 1.8e-93 3499
15 years 0.01 2.09 [1.85, 2.35] 5.8e-34 1373
5 years 0.01 3.82 [3.40, 4.29] <1e-100 1119
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ASTHMA_NAS – Asthma, unspecified (mode)
GWS hits: 22

Survival analyses between endpoints

Plot

before Asthma, unspecified (mode)
after Asthma, unspecified (mode)

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Drugs most likely to be purchased after Asthma, unspecified (mode)

Endpoint not on priority list, no data to show.