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Allergic asthma (mode)

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ALLERG_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Check mode of ICD-10 codes: %J450
Hospital Discharge: ICD-10 J45.0
Cause of death: ICD-10 J45.0

2 out of 7 registries used, show all original rules.

11139

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Check minimum number of events None

11139

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Include endpoints None

11139

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Remove individuals based on genotype QC

10723

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ALLERG_ASTHMA

Control definitions

Control exclude J10_ASTHMA, ASTHMA_EXCL

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 10723 7099 3624
Unadjusted prevalence (%) 2.60 3.08 1.99
Mean age at first event (years) 36.94 36.38 38.02

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.55 [1.05, 2.30] 2.7e-2 581
15 years 0.01 1.22 [0.89, 1.65] 2.1e-1 243
5 years 0.00 2.29 [1.74, 3.01] 3.6e-9 131
1 year 0.00 6.81 [5.00, 9.26] 2.3e-34 72

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ALLERG_ASTHMA – Allergic asthma (mode)
GWS hits: 28

Survival analyses between endpoints

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Plot

before Allergic asthma (mode)
after Allergic asthma (mode)

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Drugs most likely to be purchased after Allergic asthma (mode)

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Endpoint not on priority list, no data to show.