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Viral infections of the central nervous system

DOID EFO MESH SNOMED Endpoint Browser PheWeb

AB1_VIRAL_CNS

viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 A80-A89
Hospital discharge: ICD-9 04[5-9]|071|06[2-4]
Hospital discharge: ICD-8 04[0-3]|06[2-5]|071
Cause of death: ICD-10 A80-A89
Cause of death: ICD-9 04[5-9]|071|06[2-4]
Cause of death: ICD-8 04[0-3]|06[2-5]|071

2 out of 7 registries used, show all original rules.

2146

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Check minimum number of events None

2146

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Include endpoints

2434

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Remove individuals based on genotype QC

2332

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AB1_VIRAL_CNS

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 2332 1393 939
Unadjusted prevalence (%) 0.57 0.61 0.52
Mean age at first event (years) 38.73 37.16 41.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.57 [1.51, 4.40] 5.5e-4 271
15 years 0.01 1.58 [1.01, 2.47] 4.6e-2 79
5 years 0.01 4.44 [3.05, 6.49] 1.0e-14 60
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AB1_VIRAL_CNS – Viral infections of the central nervous system
GWS hits:

Survival analyses between endpoints

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Plot

before Viral infections of the central nervous system
after Viral infections of the central nervous system

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Drugs most likely to be purchased after Viral infections of the central nervous system

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Endpoint not on priority list, no data to show.