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Infections with a predominantly sexual mode of transmission

DOID EFO MESH SNOMED Endpoint Browser PheWeb

AB1_SEXUAL_TRANSMISSION

tabes dorsalis: A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 A50-A64
Hospital discharge: ICD-9 09[0-9]|0541|131|0781C
Hospital discharge: ICD-8 09[0-9]|131
Cause of death: ICD-10 A50-A64
Cause of death: ICD-9 09[0-9]|0541|131|0781C
Cause of death: ICD-8 09[0-9]|131

2 out of 7 registries used, show all original rules.

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Check minimum number of events None

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Include endpoints

12557

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Remove individuals based on genotype QC

11984

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AB1_SEXUAL_TRANSMISSION

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 11984 8892 3092
Unadjusted prevalence (%) 2.91 3.86 1.70
Mean age at first event (years) 32.51 31.16 36.37

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.87 [1.37, 2.55] 8.2e-5 440
15 years 0.01 1.29 [0.95, 1.75] 9.8e-2 151
5 years 0.00 2.66 [1.95, 3.64] 9.7e-10 75
1 year 0.00 5.09 [3.27, 7.91] 5.1e-13 26

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AB1_SEXUAL_TRANSMISSION – Infections with a predominantly sexual mode of transmission
GWS hits:

Survival analyses between endpoints

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Plot

before Infections with a predominantly sexual mode of transmission
after Infections with a predominantly sexual mode of transmission

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Drugs most likely to be purchased after Infections with a predominantly sexual mode of transmission

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Endpoint not on priority list, no data to show.